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Post hoc mediation analysis across SURPASS-1 through SURPASS-5 found that decreases in systolic blood pressure (ranging from 1.3 mmHg to 11.5 mmHg across the tirzepatide doses) were primarily mediated through weight loss [91]

Br J Community Nurs Apr

Clinical trials show patients who discontinue treatment regain approximately two-thirds of lost weight over the following year, while A1C levels typically rise as the medication's metabolic effects cease

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Sustainable weight loss still requires dietary changes, physical activity, and consistency

A: Tirzepatide is a prescription medication designed to support weight loss and blood sugar control by helping regulate appetite, metabolism, and glucose levels in the body